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A yeast-based complementation assay elucidates the functional impact of 200 missense variants in human PSAT1

BACKGROUND: Defects in serine biosynthesis caused by loss of function mutations in PHGDH, PSAT1, and PSPH cause a set of rare, autosomal recessive diseases known as Neu-Laxova syndrome (NLS) or serine-deficiency disorders. The diseases present with a broad range of phenotypes including lethality, se...

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Detalhes bibliográficos
Publicado no:J Inherit Metab Dis
Main Authors: Sirr, Amy, Lo, Russell S., Cromie, Gareth A., Scott, Adrian C., Ashmead, Julee, Heyesus, Mirutse, Dudley, Aimée M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7444316/
https://ncbi.nlm.nih.gov/pubmed/32077105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jimd.12227
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