Allelic Variation, Aneuploidy, and Nongenetic Mechanisms Suppress a Monogenic Trait in Yeast

Clinically relevant features of monogenic diseases, including severity of symptoms and age of onset, can vary widely in response to environmental differences as well as to the presence of genetic modifiers affecting the trait’s penetrance and expressivity. While a better understanding of modifier lo...

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Bibliografiske detaljer
Udgivet i:Genetics
Main Authors: Sirr, Amy, Cromie, Gareth A., Jeffery, Eric W., Gilbert, Teresa L., Ludlow, Catherine L., Scott, Adrian C., Dudley, Aimée M.
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2015
Fag:
Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286688/
https://ncbi.nlm.nih.gov/pubmed/25398792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.170563
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