Long-read individual-molecule sequencing reveals CRISPR-induced genetic heterogeneity in human ESCs

Quantifying the genetic heterogeneity of a cell population is essential to understanding of biological systems. We develop a universal method to label individual DNA molecules for single-base-resolution haplotype-resolved quantitative characterization of diverse types of rare variants, with frequenc...

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Vydáno v:Genome Biol
Hlavní autoři: Bi, Chongwei, Wang, Lin, Yuan, Baolei, Zhou, Xuan, Li, Yu, Wang, Sheng, Pang, Yuhong, Gao, Xin, Huang, Yanyi, Li, Mo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7444080/
https://ncbi.nlm.nih.gov/pubmed/32831134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02143-8
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