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Long-read individual-molecule sequencing reveals CRISPR-induced genetic heterogeneity in human ESCs
Quantifying the genetic heterogeneity of a cell population is essential to understanding of biological systems. We develop a universal method to label individual DNA molecules for single-base-resolution haplotype-resolved quantitative characterization of diverse types of rare variants, with frequenc...
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| Publicado no: | Genome Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7444080/ https://ncbi.nlm.nih.gov/pubmed/32831134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02143-8 |
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