Genome-wide RNA interference screening reveals a COPI-MAP2K3 pathway required for YAP regulation

The transcriptional regulator YAP, which plays important roles in the development, regeneration, and tumorigenesis, is activated when released from inhibition by the Hippo kinase cascade. The regulatory mechanism of YAP in Hippo-low contexts is poorly understood. Here, we performed a genome-wide RNA...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kim, Yong Joon, Jung, Eunji, Shin, Eunbie, Hong, Sin-Hyoung, Jeong, Hui Su, Hur, Gayeong, Jeong, Hye Yun, Lee, Seung-Hyo, Lee, Ji Eun, Kim, Gun-Hwa, Kim, Joon
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443978/
https://ncbi.nlm.nih.gov/pubmed/32747557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915387117
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