Identification of MYC as an antinecroptotic protein that stifles RIPK1–RIPK3 complex formation

The underlying mechanism of necroptosis in relation to cancer is still unclear. Here, MYC, a potent oncogene, is an antinecroptotic factor that directly suppresses the formation of the RIPK1–RIPK3 complex. Gene set enrichment analyses reveal that the MYC pathway is the most prominently down-regulate...

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Opis bibliograficzny
Wydane w:Proc Natl Acad Sci U S A
Główni autorzy: Seong, Daehyeon, Jeong, Manhyung, Seo, Jinho, Lee, Ji-Yoon, Hwang, Chi Hyun, Shin, Ho-Chul, Shin, Jeong Yoon, Nam, Young Woo, Jo, Jeong Yeon, Lee, Haeseung, Kim, Hye-Jung, Kim, Hwa-Ryeon, Oh, Ji Hoon, Ha, Sang-Jun, Kim, Seung Jun, Roe, Jae-Seok, Kim, Wankyu, Cheong, June-Won, Bae, Kwang-Hee, Lee, Sang Chul, Oberst, Andrew, Vandenabeele, Peter, Shin, Dong Hoon, Lee, Eun-Woo, Song, Jaewhan
Format: Artigo
Język:Inglês
Wydane: National Academy of Sciences 2020
Hasła przedmiotowe:
Biological Sciences
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443878/
https://ncbi.nlm.nih.gov/pubmed/32753382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000979117
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