A novel colistin adjuvant identified by virtual screening for ArnT inhibitors

BACKGROUND: Colistin is a last-resort treatment option for many MDR Gram-negative bacteria. The covalent addition of l-aminoarabinose to the lipid A moiety of LPS is the main colistin resistance mechanism in the human pathogen Pseudomonas aeruginosa. OBJECTIVES: Identification (by in silico screenin...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Antimicrob Chemother
मुख्य लेखकों: Ghirga, Francesca, Stefanelli, Roberta, Cavinato, Luca, Lo Sciuto, Alessandra, Corradi, Silvia, Quaglio, Deborah, Calcaterra, Andrea, Casciaro, Bruno, Loffredo, Maria Rosa, Cappiello, Floriana, Morelli, Patrizia, Antonelli, Alberto, Rossolini, Gian Maria, Mangoni, Marialuisa, Mancone, Carmine, Botta, Bruno, Mori, Mattia, Ascenzioni, Fiorentina, Imperi, Francesco
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2020
विषय:
Original Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443731/
https://ncbi.nlm.nih.gov/pubmed/32514531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa200
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