Optimization of flucloxacillin dosing regimens in critically ill patients using population pharmacokinetic modelling of total and unbound concentrations

BACKGROUND: Initial appropriate anti-infective therapy is associated with improved outcomes in patients with severe infections. In critically ill patients, altered pharmacokinetic (PK) behaviour is common and known to influence the achievement of PK/pharmacodynamic targets. OBJECTIVES: To describe p...

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Vydáno v:J Antimicrob Chemother
Hlavní autoři: Jager, Nynke G L, van Hest, Reinier M, Xie, Jiao, Wong, Gloria, Ulldemolins, Marta, Brüggemann, Roger J M, Lipman, Jeffrey, Roberts, Jason A
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443729/
https://ncbi.nlm.nih.gov/pubmed/32443147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa187
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