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Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalized patients with Staphylococcus aureus bacteraemia
AIMS: Flucloxacillin dosing may be guided by measurement of its total plasma concentrations. Flucloxacillin is highly protein bound with fraction unbound in plasma (f(u)) of around 0.04 in healthy individuals. The utility of measuring unbound flucloxacillin concentrations for patients outside the in...
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| Publicado no: | Br J Clin Pharmacol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6138478/ https://ncbi.nlm.nih.gov/pubmed/29908071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13673 |
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