The barley lectin, horcolin, binds high-mannose glycans in a multivalent fashion, enabling high-affinity, specific inhibition of cellular HIV infection

N-Linked glycans are critical to the infection cycle of HIV, and most neutralizing antibodies target the high-mannose glycans found on the surface envelope glycoprotein-120 (gp120). Carbohydrate-binding proteins, particularly mannose-binding lectins, have also been shown to bind these glycans. Despi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jayaprakash, Nisha Grandhi, Singh, Amrita, Vivek, Rahul, Yadav, Shivender, Pathak, Sanmoy, Trivedi, Jay, Jayaraman, Narayanaswamy, Nandi, Dipankar, Mitra, Debashis, Surolia, Avadhesha
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443486/
https://ncbi.nlm.nih.gov/pubmed/32636304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013100
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