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Interleukin-6–mediated epigenetic control of the VEGFR2 gene induces disorganized angiogenesis in human breast tumors

Disorganized vessels in the tumor vasculature lead to impaired perfusion, resulting in reduced accessibility to immune cells and chemotherapeutic drugs. In the breast tumor–stroma interplay, paracrine factors such as interleukin-6 (IL-6) often facilitate disordered angiogenesis. We show here that ep...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Hegde, Mangala, Guruprasad, Kanive Parashiva, Ramachandra, Lingadakai, Satyamoorthy, Kapaettu, Joshi, Manjunath B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443485/
https://ncbi.nlm.nih.gov/pubmed/32636303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012590
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