Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse

BACKGROUND AND PURPOSE: Genetic deletion and pharmacological studies suggest a role for lysophosphatidic acid (LPA(1)) receptor in fibrosis. We investigated the therapeutic potential in systemic sclerosis (SSc) of a new orally active selective LPA(1) receptor antagonist using dermal fibroblasts from...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Ledein, Laetitia, Léger, Bertrand, Dees, Clara, Beyer, Christian, Distler, Alfiya, Vettori, Serena, Boukaiba, Rachid, Bidouard, Jean Pierre, Schaefer, Matthias, Pernerstorfer, Josef, Ruetten, Hartmut, Jagerschmidt, Alexandre, Janiak, Philip, Distler, Jörg H.W., Distler, Oliver, Illiano, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443477/
https://ncbi.nlm.nih.gov/pubmed/32627178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15190
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