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Regulation of gene expression by MF63, a selective inhibitor of microsomal PGE synthase 1 (mPGES1) in human osteoarthritic chondrocytes

BACKGROUND AND PURPOSE: mPGES1 catalyses the production of PGE(2), the most abundant prostanoid related to inflammation and pain in arthritis. mPGES1 is suggested to be a safer and more selective drug target in inflammatory conditions compared to the COX enzymes inhibited by NSAIDs. In the present s...

詳細記述

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書誌詳細
出版年:Br J Pharmacol
主要な著者: Tuure, Lauri, Pemmari, Antti, Hämäläinen, Mari, Moilanen, Teemu, Moilanen, Eeva
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443472/
https://ncbi.nlm.nih.gov/pubmed/32449517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15142
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