The bromodomain inhibitor IBET-151 attenuates vismodegib-resistant esophageal adenocarcinoma growth through reduction of GLI signaling

The Hedgehog/GLI (HH/GLI) signaling pathway plays a critical role in human oncogenesis. Unfortunately, the clinical use of HH inhibitor(s) has been associated with serious adverse effects and mutation-related drug resistance. Since the efficacy of SMO (Smoothened) and GLI inhibitors is limited in cl...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Alvarez-Trotta, Annamil, Wang, Zhiqiang, Shersher, Elena, Li, Bin, Long, Jun, Lohse, Ines, Wahlestedt, Claes, El-Rifai, Wael, Robbins, David J., Capobianco, Anthony J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443367/
https://ncbi.nlm.nih.gov/pubmed/32913560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27699
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