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Endothelial MAP2K1 Mutations in Arteriovenous Malformation Activate the RAS/MAPK Pathway
Arteriovenous malformation (AVM) is a locally destructive congenital vascular anomaly caused by somatic mutations in MAP2K1. The mutation is isolated to endothelial cells (ECs). The purpose of this study was to determine the effects of mutant MAP2K1 on EC signaling and vascular network formation. Pa...
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| Vydáno v: | Biochem Biophys Res Commun |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7443257/ https://ncbi.nlm.nih.gov/pubmed/32703450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.06.022 |
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