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Endothelial MAP2K1 Mutations in Arteriovenous Malformation Activate the RAS/MAPK Pathway
Arteriovenous malformation (AVM) is a locally destructive congenital vascular anomaly caused by somatic mutations in MAP2K1. The mutation is isolated to endothelial cells (ECs). The purpose of this study was to determine the effects of mutant MAP2K1 on EC signaling and vascular network formation. Pa...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7443257/ https://ncbi.nlm.nih.gov/pubmed/32703450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.06.022 |
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