Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation

Th17 cells, a lymphocyte subpopulation that is characterized by the expression of the transcription factor “retinoic acid receptor-related orphan receptor gamma-t” (RORγt), plays an important role in the pathogenesis of autoimmune disease. The current study was set up to discover novel and non-stero...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Tan, Jun, Liu, Huan, Huang, Minhao, Li, Na, Tang, Shibing, Meng, Jiayu, Tang, Shiyun, Zhou, Hongxiu, Kijlstra, Aize, Yang, Peizeng, Hou, Shengping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443190/
https://ncbi.nlm.nih.gov/pubmed/32829384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02891-2
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