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Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins

Manufacturing of biopharmaceuticals involves recombinant protein expression in host cells followed by extensive purification of the target protein. Yet, host cell proteins (HCPs) may persist in the final drug product, potentially reducing its quality with respect to safety and efficacy. Consequently...

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Bibliografski detalji
Izdano u:Anal Bioanal Chem
Glavni autori: Esser-Skala, Wolfgang, Segl, Marius, Wohlschlager, Therese, Reisinger, Veronika, Holzmann, Johann, Huber, Christian G.
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442769/
https://ncbi.nlm.nih.gov/pubmed/32691086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-020-02796-1
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