Mapping Systemic Lupus Erythematosus heterogeneity at the single-cell level

Patients with Systemic Lupus Erythematosus (SLE) display a complex blood transcriptome whose cellular origin is poorly resolved. Using single-cell RNA-seq, we profiled ~276,000 PBMCs from 33 children with SLE (cSLE) with different degrees of disease activity (DA) and 11 matched controls. Increased e...

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Publicado en:Nat Immunol
Autores principales: Nehar-Belaid, Djamel, Hong, Seunghee, Marches, Radu, Chen, Guo, Bolisetty, Mohan, Baisch, Jeanine, Walters, Lynnette, Punaro, Marilynn, Rossi, Robert J., Chung, Cheng-Han, Huynh, Richie P., Singh, Prashant, Flynn, William F., Tabanor-Gayle, Joy-Ann, Kuchipudi, Navya, Mejias, Asuncion, Collet, Magalie A., Lucido, Anna Lisa, Palucka, Karolina, Robson, Paul, Lakshminarayanan, Santhanam, Ramilo, Octavio, Wright, Tracey, Pascual, Virginia, Banchereau, Jacques F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442743/
https://ncbi.nlm.nih.gov/pubmed/32747814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0743-0
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