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A novel flow-cytometric assay to identify inhibitors of RBPJ-DNA interactions

Notch signaling is often involved in cancer cell initiation and proliferation. Aberrant Notch activation underlies more than 50% of T-cell Acute Lymphoblastic Leukemia (T-ALL); accordingly, chemicals disrupting Notch signaling are of potential to treat Notch-dependent cancer. Here, we developed a fl...

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Podrobná bibliografie
Vydáno v:SLAS Discov
Hlavní autoři: Lake, Robert J., Haynes, Mark K., Dreval, Kostiantyn, Bilkis, Rabeya, Sklar, Larry A, Fan, Hua-Ying
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442708/
https://ncbi.nlm.nih.gov/pubmed/32567455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555220932552
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