Identification of a potent and selective covalent Pin1 inhibitor

Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is commonly overexpressed in human cancers, including pancreatic ductal adenocarcinoma (PDAC). While Pin1 is dispensable for viability in mice, it is required for activated Ras to induce tumorigenesis, suggesting a role for Pin1 inhibitor...

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Gepubliceerd in:Nat Chem Biol
Hoofdauteurs: Pinch, Benika J., Doctor, Zainab M., Nabet, Behnam, Browne, Christopher M., Seo, Hyuk-Soo, Mohardt, Mikaela L., Kozono, Shingo, Lian, Xiaolan, Manz, Theresa D., Chun, Yujin, Kibe, Shin, Zaidman, Daniel, Daitchman, Dina, Yeoh, Zoe C., Vangos, Nicholas E., Geffken, Ezekiel A., Tan, Li, Ficarro, Scott B., London, Nir, Marto, Jarrod A., Buratowski, Stephen, Dhe-Paganon, Sirano, Zhou, Xiao Zhen, Lu, Kun Ping, Gray, Nathanael S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442691/
https://ncbi.nlm.nih.gov/pubmed/32483379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0550-9
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