Effects of Colesevelam on Bowel Symptoms, Biomarkers, and Colonic Mucosal Gene Expression in Patients with Bile Acid Diarrhea in a Randomized Trial

BACKGROUND & AIMS: Approximately one-third of patients with IBS-diarrhea (IBS-D) have increased bile acid (BA) synthesis or excretion. An open-label study showed benefits of colesevelam on bowel functions, consistent with luminal BA sequestration by colesevelam. We compared the effects of colese...

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Detalhes bibliográficos
Publicado no:Clin Gastroenterol Hepatol
Main Authors: Vijayvargiya, Priya, Camilleri, Michael, Carlson, Paula, Nair, Asha, Nord, Sara Linker, Ryks, Michael, Rhoten, Deborah, Burton, Duane, Busciglio, Irene, Lueke, Alan, Harmsen, W. Scott, Donato, Leslie J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442687/
https://ncbi.nlm.nih.gov/pubmed/32088296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cgh.2020.02.027
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