Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore

BACKGROUND: Despite significant endeavor having been applied to identify effective therapies to treat glioblastoma (GBM), survival outcomes remain intractable. The greatest nonsurgical benefit arises from radiotherapy, though tumors typically recur due to robust DNA repair. Patients could therefore...

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Vydáno v:Neuro Oncol
Hlavní autoři: Lim, Yi Chieh, Ensbey, Kathleen S, Offenhäuser, Carolin, D’souza, Rochelle C J, Cullen, Jason K, Stringer, Brett W, Quek, Hazel, Bruce, Zara C, Kijas, Amanda, Cianfanelli, Valentina, Mahboubi, Bijan, Smith, Fiona, Jeffree, Rosalind L, Wiesmüeller, Lisa, Wiegmans, Adrian P, Bain, Amanda, Lombard, Fanny J, Roberts, Tara L, Khanna, Kum Kum, Lavin, Martin F, Kim, Baek, Hamerlik, Petra, Johns, Terrance G, Coster, Mark J, Boyd, Andrew W, Day, Bryan W
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442340/
https://ncbi.nlm.nih.gov/pubmed/31504812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz159
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