Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore

BACKGROUND: Despite significant endeavor having been applied to identify effective therapies to treat glioblastoma (GBM), survival outcomes remain intractable. The greatest nonsurgical benefit arises from radiotherapy, though tumors typically recur due to robust DNA repair. Patients could therefore...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Lim, Yi Chieh, Ensbey, Kathleen S, Offenhäuser, Carolin, D’souza, Rochelle C J, Cullen, Jason K, Stringer, Brett W, Quek, Hazel, Bruce, Zara C, Kijas, Amanda, Cianfanelli, Valentina, Mahboubi, Bijan, Smith, Fiona, Jeffree, Rosalind L, Wiesmüeller, Lisa, Wiegmans, Adrian P, Bain, Amanda, Lombard, Fanny J, Roberts, Tara L, Khanna, Kum Kum, Lavin, Martin F, Kim, Baek, Hamerlik, Petra, Johns, Terrance G, Coster, Mark J, Boyd, Andrew W, Day, Bryan W
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442340/
https://ncbi.nlm.nih.gov/pubmed/31504812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz159
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