Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors

Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H (RNase H) remains as the only enzyme encoded within the viral genome not targeted by current antiviral drugs. In this work, we report the design, synthesis, and biologic evaluation of a novel series of galloyl de...

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Publicado en:Chem Biol Drug Des
Autores principales: Gao, Ping, Wang, Xueshun, Sun, Lin, Cheng, Xiqiang, Poongavanam, Vasanthanathan, Kongsted, Jacob, Álvarez, Mar, Luczkowiak, Joanna, Pannecouque, Christophe, De Clercq, Erik, Lee, Kuo-Hsiung, Chen, Chin-Ho, Liu, Huiqing, Menéndez-Arias, Luis, Liu, Xinyong, Zhan, Peng
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441570/
https://ncbi.nlm.nih.gov/pubmed/30560566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13455
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