Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties

To address drug resistance to HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs), a series of novel diarylpyrimidine (DAPY) derivatives targeting “tolerant region I” and “tolerant region II” of the NNRTIs binding pocket (NNIBP) were designed utilizing a structure-guided scaffold-hopping...

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Publicado no:J Med Chem
Main Authors: Kang, Dongwei, Zhang, Heng, Wang, Zhao, Zhao, Tong, Ginex, Tiziana, Luque, Francisco Javier, Yang, Yang, Wu, Gaochan, Feng, Da, Wei, Fenju, Zhang, Jian, De Clercq, Erik, Pannecouque, Christophe, Chen, Chin Ho, Lee, Kuo-Hsiung, Murugan, N. Arul, Steitz, Thomas A., Zhan, Peng, Liu, Xinyong
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441537/
https://ncbi.nlm.nih.gov/pubmed/30624934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01656
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