2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-κB Signalling Pathways in Lung Cancer A549 Cells

Two novel compounds, 2-(2-hydroxyethylthio)-5,8-dimethoxy-1,4-naphthoquinone (HEDMNQ) and 2-(6-hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone (HHDMNQ), were synthesized to investigate the kill effects and mechanism of 1,4-naphthoquinone derivatives in lung cancer cells. The results of the CCK-8...

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Bibliographic Details
Published in:Evid Based Complement Alternat Med
Main Authors: Shen, Gui-Nan, Wang, Cheng, Luo, Ying-Hua, Wang, Jia-Ru, Wang, Rui, Xu, Wan-Ting, Zhang, Yi, Zhang, Yu, Zhang, Dong-Jie, Jin, Cheng-Hao
Format: Artigo
Language:Inglês
Published: Hindawi 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7441457/
https://ncbi.nlm.nih.gov/pubmed/32849902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/7375862
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