2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone inhibits LPS-induced BV2 microglial activation through MAPK/NF-kB signaling pathways

AIMS: To verify the effects of several 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) derivatives on LPS-induced NO production, cellular ROS levels and cytokine expression in BV-2 microglial cells. MAIN METHODS: An MTT assay and FACS flow cytometry were performed to assess the cellular viability and apopto...

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Publicado en:Heliyon
Autores principales: Sun, Hu-Nan, Shen, Gui-Nan, Jin, Yong-Zhe, Jin, Yu, Han, Ying-Hao, Feng, Li, Liu, Lei, Jin, Mei-Hua, Luo, Ying-Hua, Kwon, Tea-Ho, Cui, Yu-Dong, Jin, Cheng-Hao
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971128/
https://ncbi.nlm.nih.gov/pubmed/27512726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2016.e00132
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