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A high-throughput SAMDI-mass spectrometry assay for isocitrate dehydrogenase 1
The enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the conversion of isocitrate to alpha-ketoglutarate (αKG) and has emerged as an important therapeutic target for glioblastoma multiforme (GBM). Current methods for assaying IDH1 remain poorly suited for high-throughput screening of IDH1 antagoni...
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| Veröffentlicht in: | Analyst |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7440924/ https://ncbi.nlm.nih.gov/pubmed/32297889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0an00174k |
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