Epigenomically Bistable Regions across Neuron-Specific Genes Govern Neuron Eligibility to a Coding Ensemble in the Hippocampus

Sensory inputs activate sparse neuronal ensembles in the dentate gyrus of the hippocampus, but how eligibility of individual neurons to recruitment is determined remains elusive. We identify thousands of largely bistable (CpG methylated or unmethylated) regions within neuronal gene bodies, establish...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Odell, Shannon C., Taki, Faten, Klein, Shifra Liba, Chen, Rosa J., Levine, Olivia B., Skelly, Mary Jane, Nabila, Anika, Brindley, Elizabeth, Toth, Judit Gal, Dündar, Friederike, Sheridan, Caroline K., Fetcho, Robert N., Alonso, Alicia, Liston, Conor, Landau, Dan A., Pleil, Kristen E., Toth, Miklos
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7440841/
https://ncbi.nlm.nih.gov/pubmed/32579919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107789
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