Epigenomically Bistable Regions across Neuron-Specific Genes Govern Neuron Eligibility to a Coding Ensemble in the Hippocampus

Sensory inputs activate sparse neuronal ensembles in the dentate gyrus of the hippocampus, but how eligibility of individual neurons to recruitment is determined remains elusive. We identify thousands of largely bistable (CpG methylated or unmethylated) regions within neuronal gene bodies, establish...

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Pubblicato in:Cell Rep
Autori principali: Odell, Shannon C., Taki, Faten, Klein, Shifra Liba, Chen, Rosa J., Levine, Olivia B., Skelly, Mary Jane, Nabila, Anika, Brindley, Elizabeth, Toth, Judit Gal, Dündar, Friederike, Sheridan, Caroline K., Fetcho, Robert N., Alonso, Alicia, Liston, Conor, Landau, Dan A., Pleil, Kristen E., Toth, Miklos
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7440841/
https://ncbi.nlm.nih.gov/pubmed/32579919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107789
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