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Can the Cecal Ligation and Puncture Model Be Repurposed To Better Inform Therapy in Human Sepsis?

A recent report by the National Institutes of Health on sepsis research has implied there is a trend to move away from mouse models of sepsis. The most commonly used animal model to study the pathogenesis of human sepsis is cecal ligation and puncture (CLP) in mice. The model has been the mainstay o...

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Bibliografiske detaljer
Udgivet i:Infect Immun
Main Authors: Alverdy, John C., Keskey, Robert, Thewissen, Renee
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7440761/
https://ncbi.nlm.nih.gov/pubmed/32571986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00942-19
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