MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling

BACKGROUND: Microglial polarization is a dynamic response to acute brain hypoxia induced by stroke and traumatic brain injury (TBI). However, studies on the polarization of microglia in chronic cerebral circulation insufficiency (CCCI) are limited. Our objective was to investigate the effect of CCCI...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Mao, Meng, Xu, Yi, Zhang, Xin-Yu, Yang, Lin, An, Xiao-bin, Qu, Yang, Chai, Ya-ni, Wang, Yan-Ru, Li, Ting-ting, Ai, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439693/
https://ncbi.nlm.nih.gov/pubmed/32819407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01919-w
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