Microglial CX(3)CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX(3)CL1

Homo and heterozygote cx3cr1 mutant mice, which harbor a green fluorescent protein (EGFP) in their cx3cr1 loci, represent a widely used animal model to study microglia and peripheral myeloid cells. Here we report that microglia in the dentate gyrus (DG) of cx3cr1(−/−) mice displayed elevated microgl...

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Dettagli Bibliografici
Pubblicato in:Acta Neuropathol Commun
Autori principali: Sellner, Sabine, Paricio-Montesinos, Ricardo, Spieß, Alena, Masuch, Annette, Erny, Daniel, Harsan, Laura A., Elverfeldt, Dominik v., Schwabenland, Marius, Biber, Knut, Staszewski, Ori, Lira, Sergio, Jung, Steffen, Prinz, Marco, Blank, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027111/
https://ncbi.nlm.nih.gov/pubmed/27639555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0374-8
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