Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution

Intrinsically disordered proteins (IDPs) can be degraded in a ubiquitin-independent process by the 20S proteasome. Decline in 20S activity characterizes neurodegenerative diseases. Here, we examine 20S degradation of IDP tau, a protein that aggregates into insoluble deposits in Alzheimer’s disease....

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Foilsithe in:Sci Adv
Main Authors: Ukmar-Godec, T., Fang, P., Ibáñez de Opakua, A., Henneberg, F., Godec, A., Pan, K.-T., Cima-Omori, M.-S., Chari, A., Mandelkow, E., Urlaub, H., Zweckstetter, M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Association for the Advancement of Science 2020
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439447/
https://ncbi.nlm.nih.gov/pubmed/32832664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba3916
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