Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4(+) T cells ex vivo

Although combination antiretroviral therapy is effective in controlling HIV-1 infection, latent HIV-1 proviruses cannot be eliminated. HIV-1 reactivation induced by the mere use of latency-reversing agents is insufficient to render death of reservoir cells, indicating that certain intrinsic survival...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Zhou, Dawei, Hayashi, Tsuyoshi, Jean, Maxime, Kong, Weili, Fiches, Guillaume, Biswas, Ayan, Liu, Shuai, Yosief, Hailemichael O., Zhang, Xiaofeng, Bradner, Jay, Qi, Jun, Zhang, Wei, Santoso, Netty, Zhu, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439358/
https://ncbi.nlm.nih.gov/pubmed/32832623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba1941
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