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Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics
Genetic studies have identified variants in the LRRK2 gene as important components of Parkinson’s disease (PD) pathobiology. Biochemical and emergent biomarker studies have coalesced around LRRK2 hyperactivation in disease. Therapeutics that diminish LRRK2 activity, either with small molecule kinase...
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| Pubblicato in: | Front Neurosci |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7438883/ https://ncbi.nlm.nih.gov/pubmed/32903744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00807 |
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