Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells

Colorectal cancer (CRC) is a leading cause of cancer death. Chemoresistance is a pivotal feature of cancer cells leading to treatment failure and ATP-binding cassette (ABC) transporters are responsible for the efflux of several molecules, including anticancer drugs. The Hedgehog-GLI (HH-GLI) pathway...

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Publicat a:Sci Rep
Autors principals: Po, Agnese, Citarella, Anna, Catanzaro, Giuseppina, Besharat, Zein Mersini, Trocchianesi, Sofia, Gianno, Francesca, Sabato, Claudia, Moretti, Marta, De Smaele, Enrico, Vacca, Alessandra, Fiori, Micol Eleonora, Ferretti, Elisabetta
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438531/
https://ncbi.nlm.nih.gov/pubmed/32814794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70871-9
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