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Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming
Arginine auxotrophy due to the silencing of argininosuccinate synthetase 1 (ASS1) occurs in many carcinomas and in the majority of sarcomas. Arginine deiminase (ADI-PEG20) therapy exploits this metabolic vulnerability by depleting extracellular arginine, causing arginine starvation. ASS1-negative ce...
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| 出版年: | Cell Death Dis |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7438517/ https://ncbi.nlm.nih.gov/pubmed/32814773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02899-8 |
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