Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive cancers. To assess the metabolic effects that a...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Kremer, Jeff Charles, Prudner, Bethany Cheree, Lange, Sara Elaine Stubbs, Bean, Gregory Richard, Schultze, Matthew Bailey, Brashears, Caitlyn Brook, Radyk, Megan DeAnna, Redlich, Nathan, Tzeng, Shin-Cheng, Kami, Kenjiro, Shelton, Laura, Li, Aixiao, Morgan, Zack, Bomalaski, John Stephen, Tsukamoto, Takashi, McConathy, Jon, Michel, Loren Scott, Held, Jason Matthew, Van Tine, Brian Andrew
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840045/
https://ncbi.nlm.nih.gov/pubmed/28122247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.077
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