Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model

BACKGROUND: Long QT syndrome type 3 (LQT3) is caused by gain-of-function mutations in the SCN5A gene, which encodes the α subunit of the cardiac voltage-gated sodium channel. LQT3 patients present bradycardia and lethal arrhythmias during rest or sleep. Further, the efficacy of β-blockers, the drug...

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Pubblicato in:Front Cell Dev Biol
Autori principali: Hirose, Sayako, Makiyama, Takeru, Melgari, Dario, Yamamoto, Yuta, Wuriyanghai, Yimin, Yokoi, Fumika, Nishiuchi, Suguru, Harita, Takeshi, Hayano, Mamoru, Kohjitani, Hirohiko, Gao, Jingshan, Kashiwa, Asami, Nishikawa, Misato, Wu, Jie, Yoshimoto, Jun, Chonabayashi, Kazuhisa, Ohno, Seiko, Yoshida, Yoshinori, Horie, Minoru, Kimura, Takeshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Cell and Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438478/
https://ncbi.nlm.nih.gov/pubmed/32903469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00761
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