Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia

INTRODUCTION: Human induced pluripotent stem cells (hiPSCs) offer a unique opportunity for disease modeling. However, it is not invariably successful to recapitulate the disease phenotype because of the immaturity of hiPSC-derived cardiomyocytes (hiPSC-CMs). The purpose of this study was to establis...

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Pubblicato in:PLoS One
Autori principali: Sasaki, Kenichi, Makiyama, Takeru, Yoshida, Yoshinori, Wuriyanghai, Yimin, Kamakura, Tsukasa, Nishiuchi, Suguru, Hayano, Mamoru, Harita, Takeshi, Yamamoto, Yuta, Kohjitani, Hirohiko, Hirose, Sayako, Chen, Jiarong, Kawamura, Mihoko, Ohno, Seiko, Itoh, Hideki, Takeuchi, Ayako, Matsuoka, Satoshi, Miura, Masaru, Sumitomo, Naokata, Horie, Minoru, Yamanaka, Shinya, Kimura, Takeshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072719/
https://ncbi.nlm.nih.gov/pubmed/27764147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164795
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