Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion

The mitochondrial permeability transition pore (mPTP) plays a critical role in the pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although the pore structure is still unresolved, the mechanism through which cyclophilin D (CypD) regulates mPTP opening is the subject o...

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Vydáno v:Cell Death Dis
Hlavní autoři: Hurst, Stephen, Gonnot, Fabrice, Dia, Maya, Crola Da Silva, Claire, Gomez, Ludovic, Sheu, Shey-Shing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438327/
https://ncbi.nlm.nih.gov/pubmed/32814770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02864-5
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