Repeat radiation with bevacizumab and minocycline in bevacizumab-refractory high grade gliomas: a prospective phase 1 trial

INTRODUCTION: There are no effective treatments for gliomas after progression on radiation, temozolomide, and bevacizumab. Microglia activation may be involved in radiation resistance and can be inhibited by the brain penetrating antibiotic minocycline. In this phase 1 trial, we examined the safety...

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Detalhes bibliográficos
Publicado no:J Neurooncol
Main Authors: Cohen, Adam L., Anker, Christopher J., Johnson, Brett, Burt, Lindsay M., Shrieve, Dennis C., Salzman, Karen, Jensen, Randy, Boucher, Ken, Colman, Howard
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438283/
https://ncbi.nlm.nih.gov/pubmed/32506371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-020-03551-3
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