Repeat radiation with bevacizumab and minocycline in bevacizumab-refractory high grade gliomas: a prospective phase 1 trial

INTRODUCTION: There are no effective treatments for gliomas after progression on radiation, temozolomide, and bevacizumab. Microglia activation may be involved in radiation resistance and can be inhibited by the brain penetrating antibiotic minocycline. In this phase 1 trial, we examined the safety...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Neurooncol
Main Authors: Cohen, Adam L., Anker, Christopher J., Johnson, Brett, Burt, Lindsay M., Shrieve, Dennis C., Salzman, Karen, Jensen, Randy, Boucher, Ken, Colman, Howard
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2020
Teme:
Clinical Study
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438283/
https://ncbi.nlm.nih.gov/pubmed/32506371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-020-03551-3
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