Interferon-γ signaling in human iPSC–derived neurons recapitulates neurodevelopmental disorder phenotypes

Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated cytokines, such as interferon-γ (IFN-γ), in offspring’s brains play a central role. IFN-γ activates an antiviral cellular state, limiting viral entry and replication. Moreover, IFN-γ is implicated in brain develo...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Warre-Cornish, Katherine, Perfect, Leo, Nagy, Roland, Duarte, Rodrigo R. R., Reid, Matthew J., Raval, Pooja, Mueller, Annett, Evans, Amanda L., Couch, Amalie, Ghevaert, Cédric, McAlonan, Grainne, Loth, Eva, Murphy, Declan, Powell, Timothy R., Vernon, Anthony C., Srivastava, Deepak P., Price, Jack
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438100/
https://ncbi.nlm.nih.gov/pubmed/32875100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay9506
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