Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation

The programmed death-ligand 1 (PD-L1)-dependent immune checkpoint attenuates host immunity and maintains self-tolerance. Imbalance between protective immunity and immunopathology due to altered PD-L1 signaling can lead to autoimmunity or tumor immunosuppression. The role of the PD-L1-dependent check...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Wu, Bogang, Chiang, Huai-Chin, Sun, Xiujie, Yuan, Bin, Mitra, Payal, Hu, Yanfen, Curiel, Tyler J, Li, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Basic Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7437875/
https://ncbi.nlm.nih.gov/pubmed/32817394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000964
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