Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity

G-quadruplexes (G4) are considered new drug targets for human diseases such as cancer. More than 10,000 G4s have been discovered in human chromatin, posing challenges for assessing the selectivity of a G4-interactive ligand. 3,6-bis(1-Methyl-4-vinylpyridinium) carbazole diiodide (BMVC) is the first...

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Vydáno v:Molecules
Hlavní autoři: Wu, Guanhui, Tillo, Desiree, Ray, Sreejana, Chang, Ta-Chau, Schneekloth, John S., Vinson, Charles, Yang, Danzhou
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7436161/
https://ncbi.nlm.nih.gov/pubmed/32751510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25153465
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