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Efficient Palladium-Catalyzed Synthesis of 2-Aryl Propionic Acids

A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient s...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Neumann, Helfried, Sergeev, Alexey G., Spannenberg, Anke, Beller, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7435766/
https://ncbi.nlm.nih.gov/pubmed/32731527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25153421
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