Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome

Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segment length in CA1 of the Fmr1(−/y) mouse hippocampus, with in...

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Udgivet i:Cell Rep
Main Authors: Booker, Sam A., Simões de Oliveira, Laura, Anstey, Natasha J., Kozic, Zrinko, Dando, Owen R., Jackson, Adam D., Baxter, Paul S., Isom, Lori L., Sherman, Diane L., Hardingham, Giles E., Brophy, Peter J., Wyllie, David J.A., Kind, Peter C.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7435362/
https://ncbi.nlm.nih.gov/pubmed/32783927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107988
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