IP3R-Mediated Compensatory Mechanism for Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Cardiac Ryanodine Receptor Deficiency

In adult cardiomyocytes (CMs), the type 2 ryanodine receptor (RYR2) is an indispensable Ca(2+) release channel that ensures the integrity of excitation-contraction coupling, which is fundamental for every heartbeat. However, the role and importance of RYR2 during human embryonic cardiac development...

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Опубликовано в: :Front Cell Dev Biol
Главные авторы: Luo, Xiaojing, Li, Wener, Künzel, Karolina, Henze, Sarah, Cyganek, Lukas, Strano, Anna, Poetsch, Mareike S., Schubert, Mario, Guan, Kaomei
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Cell and Developmental Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434870/
https://ncbi.nlm.nih.gov/pubmed/32903370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00772
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