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Continuous in-line homogenization process for scale-up production of naltrexone-loaded PLGA microparticles

Injectable, long-acting drug delivery systems provide effective drug concentrations in the blood for up to 6 months. Naltrexone-loaded poly(lactide-co-glycolide) (PLGA) microparticles were prepared using an in-line homogenization method. It allows the transition from a laboratory scale to scale-up p...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Sharifi, Farrokh, Otte, Andrew, Yoon, Gwangheum, Park, Kinam
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434690/
https://ncbi.nlm.nih.gov/pubmed/32645336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.06.023
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